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METOPROLOL POLPHARMA 95MG TBL N28

Attention: Information on this site is provided for informational purposes and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for treating a health problem or disease, or prescribing any medication. iDrugs24.com is not responsible for any damage to your health as the result of self treatment.

# On 2024-Mar-28
METOPROLOL-drug/medicine -tablets aproximate price on "METOPROLOL POLPHARMA 95MG TBL N28 " in Riga city, Latvia is:
  • 4.34€  4.69$  3.72£  501Rub  49.9SEK  19PLN  17.18₪ 


Maximum allowed state defined price ( from ZVA webpage) Euro:State defined maximum allowed price indicated on the picture on drug/medicine -tablets  METOPROLOL POLPHARMA 95MG TBL N28     Recheck

ATC codeC07AB02 

Active substances: Metoprololum

 


Vendor, principal: Polpharma
METOPROLOL POLPHARMA 95MG TBL N28 is compensated medicine in Latvia. 

 Prescription drug (℞) 

Similar or the same name medicines, products list *
Medicament / Item title  Prices Pharmacies chain
METOPROLOL INGEN PHARMA 95MG PAILGINTO ATPAL. TAB. N90 Rx
5.74€ , Nov.2018 Internet pharmacy Lithuania Camelia vaistine, evaistine.camelia.lt (Lithuania) Phone: 880077000Buy
* This table was compiled fully automatically, independently from any advertisers, transparently and without any modification relaying the open offers available on the mentioned dates.Only the distribution of over-the-counter remedies through the website is permitted in Latvia in accordance with national laws and regulations.
 .

METOPROLOL-RATIOPHARM RETARD 50MG N28

Package Leaflet: Information for the User

Metoprolol tartrate-ratiopharm Retard 50 mg prolonged release tablets Metoprolol tartrate-ratiopharm Retard 100 mg prolonged release tablets

Metoprolol tartrate

Read all this leaflet through carefully before you start taking this medicine because it contains important information for you.

•   Keep this leaflet. You may need to read it again.
•   If you have any further questions, ask your doctor or pharmacist.
•   This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
•   If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4

What is in this leaflet

1.   What Metoprolol-ratiopharm Retard is and what it is used for
2.   What you need to know before you take Metoprolol-ratiopharm Retard
3.   How to take Metoprolol-ratiopharm Retard
4.   Possible side-effects
5.   How to store Metoprolol-ratiopharm Retard
6.   Contents of the pack and other information

1. What Metoprolol-ratiopharm Retard is and what it is used for?

Metoprolol-ratiopharm Retard are so-called “prolonged release” tablets which give delayed release of the active substance. This blocks specific Beta-receptors in the body (Betar selective Beta-receptor blocker), thus slowing the rate at which the heart beats and reducing the blood pressure.
Metoprolol-ratiopharm Retard is used:
Adults:
-   for high blood pressure (arterial hypertension)
-   for tight chest pain due to insufficient oxygen for the heart (angina pectoris)
-   for long-term treatment after an acute heart attack
-   for rapid forms of disturbances in heart rhythm, which originate in the upper or lower heart chambers (supraventricular and ventricular tachyarrhythmias)
-   to prevent migraine
Children and adolescents from 6-18 years:
For treating high blood pressure (hypertension)

2. What you need to know before you take Metoprolol-ratiopharm Retard Do not take Metoprolol-ratiopharm Retard

-   if you are allergic to metoprolol tartrate, other beta-blockers or any of the other ingredients of this medicine (listed in section 6).
-   if you are suffering from shock due to severe heart problems
-   if you have recently suffered a heart attack and have the following special conditions (heart rate less than 45 beats per minute, abnormal ECG, the upper value of your blood pressure is less than 100 mmHg and or in case of severe heart insufficiency)..
Please ask your doctor.
-   if you suffer from untreated heart insufficiency or have certain heart rhythm disorders. Ask your doctor.
-   if your resting pulse rate is less than 50 beats per minute before treatment
-   if you suffer from a diseased sinus node in the heart (sick sinus syndrome),
-   if you suffer from very low blood pressure (hypotension: systolic blood pressure    under
90 mmHg)
-   if your blood is found to be too acid due to metabolic problems
-   if you tend to suffer from excessive bronchial spasms (e.g. severe bronchial asthma or severe chronic obstructive lung disease)
-   if you suffer from advanced blood circulation disorder in the arms or/and legs.
-   if you are taking MAO inhibitors (drugs for treating depression). MAO-B inhibitors are an exception.
-   if you have an untreated tumour of the adrenals which produces hormones (phaeochromocytoma).
Calcium antagonists of the verapamil or diltiazem types or other medicine for the treatment of irregular heartbeat (such as disopyramide) may not be given as an injection to patients being treated with Metoprolol-ratiopharm Retard. Intensive medical treatment is an exception.

Warnings and precautions

Talk to your doctor or pharmacist before taking Metoprolol-ratiopharm Retard
-   if you are suffering from minor disturbances (first degree AV block) in the transmission of excitation from the upper heart chambers to the lower heart chambers
-   if you suffer from diabetes with strongly fluctuating blood sugar values. Control regularly your blood sugar (see section 4 “Possible side-effects”).
-   if you suffer from unstable insulin-dependent diabetes
-   after protracted intense fasting and intense physical stress, as this may bring very low blood sugar
-   if you have a tumour of the adrenals which produces hormones
-   if your liver or kidney function is impaired
-   if you or a member of your family has ever suffered from psoriasis
-   if you are undergoing therapy to reduce or eliminate your tendency to react allergically (desensitization therapy; caution, severe hypersensitivity reactions) or if you have suffered a severe hypersensitivity reaction in the past
-   if you wear contact lenses.
The flow of tears could be reduced.
-   if you suffer from peripheral arterial blood circulation disorder
-   if you have problems with your thyroid
-   if there is a drop in heart rate requiring treatment and/or other complications.
-   if you suffer from breathing difficulties from constrictions in the respiratory tract (e.g. bronchial asthma or chronic obstructive lung disease),
-   if you are to undergo an operation.
Inform the anaesthesist of your treatment with Metoprolol-ratiopharm Retard.
Children and adolescents
Due to lack of therapeutic experiences Metoprolol-ratiopharm Retard should not be used in this patient group.

Other medicines and Metoprolol-ratiopharm Retard

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Inform your doctor if you are taking or using one of the following medicines:
•   Medicines to reduce blood sugar,
Insulin:
These medicines may then reduce blood sugar even more. Signs of low blood sugar concentrations (increased pulse, tremor) may be masked.
•   Medicines to reduce blood pressure or for the treatment of specific heart diseases (medicines to increase the amount of urine, medicines to expand the blood vessels, calcium antagonists [nifedipine, verapamil or diltiazem types], glycosides acting on the heart, reserpine, alpha-methyldopa, guanfacine, hydralazine or clonidine)
Greater reduction in blood pressure, greatly decreased heart rate. In a few patients, weakness of the heart muscles develops (with calcium antagonists)
•   Medicines to treat specific psychiatric diseases (medicines for depression [e.g. MAO inhibitors, paroxetine, fluoxetine, sertraline], phenothiazines, barbiturates)
Greater reduction in blood pressure
•   Medicines to treat abnormalities in heart rhythm (disopyramide)
Greater reduction in blood pressure, greatly decreased heart rate, disturbances in heart rhythm
•   Medicines for migraine which contain ergotamine Greatly decreased perfusion of the arms or legs.
•   Rifampicin (medicine for treating tuberculosis), cimetidine (medicine for reducing the production of acid in the stomach), lidocaine (medicine for local anaesthesia or for the treatment of disturbances in heart rhythm
Greater (cimetidine, lidocaine) or lesser (rifampicin) reduction in blood pressure
•   Medicines for treating colds which contain substances which reducing swelling of the mucous membranes (so-called “sympathomimetic substances”, resembling adrenaline or noradrenaline, in cough medicines or nose or eye drops)
Marked increase in blood pressure
•   Narcotics
Greater reduction in blood pressure
•   Medicines to reduce muscular tension during an operation (e.g. suxamethonium, tubocurarine)
Enhancement in the activity of these medicines
•   Medicines to decrease inflammation or pain (e.g. indomethacin or other inhibitors of prostaglandin synthetase)
Lesser reduction in blood pressure
•   Adrenaline for the treatment of a severe allergic reaction Lessened response to adrenaline

Metoprolol-ratiopharm Retard with food, drink and alcohol

You should not drink alcohol during treatment with Metoprolol-ratiopharm Retard.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Pregnancy:
Metoprolol may only be used in pregnancy (particularly in the first 3 months) after the responsible doctor has precisely evaluated the benefits and risks, as there has been no well documented study on the use of metoprolol in pregnant women. Metoprolol passes into the placenta and reduces perfusion of the placenta; this can damage the unborn child. Metoprolol should be discontinued 48-72 hours before the calculated time of birth. If this is not possible, the new born baby must be carefully monitored for 48-72 hours after the birth.
Breast feeding:
Metoprolol passes into breast milk. Undesirable effects are not to be expected after therapeutic dosages. Breast fed babies should nevertheless be observed for possible drug effects. Breast feed only 3-4 hours after taking Metoprolol-ratiopharm Retard. Thus, the amount of metoprolol taken with breast milk can be reduced.

Driving and using machines

Metoprolol-ratiopharm Retard has minor influence on the ability to drive and use machines. However, the reactions after taking the medicine differ between individuals, but can be intense enough to reduce the ability to drive, to use machines or to work without a secure hold. This applies particularly at the start of treatment, when the dose is increased, when the preparation is changed or when alcohol has been drunk.

Metoprolol-ratiopharm Retard contains sucrose (sugar)

If you have been told by your doctor that you have an intolerance to some sugars,contact your doctor before taking this medicine.

3. How to take Metoprolol-ratiopharm Retard

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
The dosage must be individually fixed - particularly after successful treatment. It may not be changed without instructions from your doctor.
If not otherwise prescribed by the doctor, the recommended dose is:
Adults
50 mg
■   High blood pressure
Tight chest pain (angina pectoris)
1   to 2 prolonged-release tablets once daily (corresponding to 50 to 100 mg metoprolol tartrate).
■   Long-term treatment after a heart attack
200 mg metoprolol tartrate once daily. For this dosage formulations with a more suitable content of active substance are available. Your doctor will prescribe the strength of dosage, as required.
■   disturbances in heart rhythm
2   prolonged-release tablets once daily (corresponding to 100 mg metoprolol tartrate).
■   Treatment to prevent migraine
2 prolonged-release tablets once daily (corresponding to 100 mg metoprolol tartrate).
The recommended dosage is 100 to 200 mg metoprolol once daily. For higher dosages (e.g. 200 mg metoprolol tartrate), use formulations with a more suitable content of active substance. Your doctor will prescribe the strength of dosage, as required.
100 mg:
■   High blood pressure
Tight chest pain (angina pectoris)
1   to 2 prolonged-release tablets once daily (corresponding to 100 to 200 mg metoprolol tartrate).
■   Long-term treatment after a heart attack
2   prolonged-release tablets once daily (corresponding to 200 mg metoprolol tartrate).
■   disturbances in heart rhythm
1 to 2 prolonged-release tablets once daily (corresponding to 100 to 200 mg metoprolol tartrate).
■   Treatment to prevent migraine
1 to 2 prolonged-release tablets once daily (corresponding to 100 to 200 mg metoprolol tartrate).
Use in children and adolescents
■   High blood pressure:
For children aged 6 years and older, the dose depends on the child’s weight. The doctor will work out the correct dose for your child.
The usual start dose is 0.5 mg/kg once a day but not exceeding 50 mg. The dose will be adjusted to the nearest tablet strength. Your doctor may increase the dose to 2.0 mg/kg depending on blood pressure response. Doses above 200 mg once daily have not been studied in children and adolescents.
Metoprolol tartrate-ratiopharm 50 mg/-100 mg/-200 mg is not recommended for children under 6 years.
Elderly, patients with renal impairement and/or hemodialysis
In the elderly the dosage ofMetoprolol-ratiopharm Retard should be adjusted very carefully. No dose adjustment is needed in patients with renal impairement.
Patients with hepatic impairement
Your doctor will reduce the dose according to your hepatic impairement.
Method of use
Prolonged-release tablets for oral use
The prolonged-release tablets are taken once daily, preferably in the morning. Please take the prolonged-release tablets without chewing and with a lot of fluid (preferably a glass of water). You can take the prolonged-release tablets independently of meals. If required, you can divide the prolonged-release tablets into equal halves.
Duration of treatment
Dosage may only be interrupted or changed on the doctor’s orders.
The duration of treatment is fixed by the responsible doctor.
Please speak with your doctor or pharmacist if you have the impression that the activity of Metoprolol-ratiopharm Retard is too strong or too weak.

If you take more Metoprolol-ratiopharm Retard than you should

If you suffer side-effects from overdose, it is best to contact a doctor, who can decide on possible action. If you suspect you have taken too much, contact a doctor or emergency doctor at once, so that they can decide what action is necessary!
Depending on the extent of the overdosage, this can lead to excessive reduction in blood pressure and a decrease in heart rate. As a consequence of the failure of heart function, this can even lead to cardiac arrest, heart muscle weakness and shock. Other symptoms include problems in breathing, constriction of the muscles in the respiratory tract, vomiting, disturbances of consciousness and even occasionally generalised seizures.
Treatment with Metoprolol-ratiopharm Retard must be discontinued after overdose or after a dangerous decrease in heart rate and/or blood pressure.

If you forget to take Metoprolol-ratiopharm Retard

Do not take a double dose to make up for a forgotten tablet.

If you stop taking Metoprolol-ratiopharm Retard

If you interrupt taking Metoprolol-ratiopharm Retard or discontinue dosage prematurely, it is essential to discuss this with your doctor. Sudden discontinuation can decrease the flow of blood through the heart muscle and this can make your angina pectoris worse. It can also lead to a myocardial infarction or to the recurrence of your high blood pressure.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side-effects, although not everybody gets them.
Very common (may affect more than 1 in 10people):
  Disturbances in the central nervous system such as tiredness (particularly at the start of treatment).
Common (may affect up to 1 in 10people):
  Giddiness, headache
•   Reduction in pulse rate, palpitation
•   Enhancement in drop in blood pressure, also when getting up from a lying position. This can very rarely lead to unconsciousness. Cold feeling in the limbs
•   Difficulty in breathing in patients with a tendency to seizures in the respiratory tract, particularly with obstructive diseases of the respiratory tract
•   Nausea, vomiting, constipation, diarrhoea, stomach ache (mostly transitory)
Uncommon (may affect up to 1 in 100people):
  Increase in weight
•   Depressive moods, concentration weakness, insomnia or sleepiness, increased dream activity
•   Tingling in the limbs
•   Disturbances in heart rhythm (disorders in the conduction from the atria to the ventricles), exacerbation of weakness of the heart muscles with peripheral pathological accumulation of fluid (oedema) in the limbs, pain in the area of the heart.
•   Constriction of the respiratory tracts in patients with a tendency to seizures of the respiratory tracts, particularly with obstructive diseases of the respiratory tract
•   Allergic skin reactions, such as reddening, itch, rash and excessive sweating
•   Cramp in the muscles
Rare (may affect up to 1 in 1,000people):
  Previously unrecognised diabetes (latent diabetes mellitus) can become evident or known diabetes mellitus can deteriorate.
•   Nervousness, anxiety
•   Inflammation of the conjunctiva, reduced flow of tears (take care if you wear contact lenses), visual disorders, irritation of the eyes
•   Disorders of conduction in the heart, arrhythmias
•   Allergic nasal congestion
•   Dry mouth
•   Changes in liver function parameters
•   Hair loss
•   Disorders in libido and potency, hardening of the connective tissue in the cavernous body of the penis (Induratio penis plastica).
Very rare (may affect up to 1 in 10,000people):
  Reduction in platelet count, reduction in white blood cell count
•   Taste disorders
•   Personality changes (e.g. fluctuations in feelings, short term loss of memory), confusion, hallucinations, disturbances in memory or difficulties in remembering
•   Hearing disorders, tinnitus
•   In patients with angina pectoris, enhancement of the attacks
•   Exacerbation of current disorders in peripheral perfusion (sometimes leading to tissue death), exacerbation of the symptoms in patients with intermittent limping (intermittent claudication) or with vascular seizures in the toes and fingers (Raynaud’s syndrome).
•   Liver inflammation
•   Sensitivity to light, with rash caused by light, psoriasis, rash resembling psoriasis
•   Joint pain, muscle weakness
Further side-effects (frequency cannot be estimated from the available data):
•   Uncontrolled anaphylactic reactions can develop in patients with severe hypersensitivity reactions in their medical history and in patients being treated to reduce or eliminate their tendency to react allergically (desensitisation therapy). See too section 2. Before you take Metoprolol-ratiopharm Retard.
•   Masking of the symptoms of severe excessive function of the thyroid
•   Disturbances in fat metabolism: Mostly normal total cholesterol, reduction in HDL-cholesterol, increase in blood triglycerides
•   After protracted severe fasting or intense physical exercise, low blood sugar may develop during treatment with Metoprolol-ratiopharm Retard. The warning signs for low blood sugar, particularly increased heart rate and trembling of the fingers, may be masked.
If you notice that you have developed signs of any of the above side-effects, please contact the doctor responsible for you. He will recommend possible treatment or may discontinue therapy with Metoprolol-ratiopharm Retard.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via www.ravimiamet.ee . By reporting side effects you can help provide more information on the safety of this medicine.

5.   How to store Metoprolol-ratiopharm Retard

Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the label and carton after.
The expiry date refers to the last day of the month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
Storage conditions:
Do not store above 30 °C.

6.   Contents of the pack and other information What Metoprolol-ratiopharm Retard contains

50 mg:
The active substance is: metoprolol tartrate (Ph.Eur.)
1 prolonged-release tablet contains 50.0 mg metoprolol tartrate (Ph.Eur.)
100 mg:
The active substance is: metoprolol tartrate (Ph.Eur.)
1 prolonged-release tablet contains 100.0 mg metoprolol tartrate (Ph.Eur.)
The other ingredients are:
microcrystalline cellulose, ethylcellulose, magnesium stearate (Ph.Eur.), hydroxypropylcellulose, triethylcitrate, silica colloidal anhydrous, hydroxypropylmethylcellulose, talc, Macrogol 6000, titanium dioxide (E 171). Sugar spheres:
sucrose, sweet corn starch, starch hydrolysate.

What Metoprolol-ratiopharm Retard looks like and contents of the pack

50 mg:
White, oblong, both-sided convex tablet with a break-score on both sides.
This prolonged-release tablet can be divided into equal halves.
100 mg:
White, oblong, both-sided convex tablet with a break-score on both sides. This prolonged-release tablet can be divided into equal halves.
PP-/Aluminiumblister
Metoprolol tartrate-ratiopharm 50 mg prolonged release tablets Metoprolol tartrate-ratiopharm 100 mg prolonged release tablets
Pack sizes with 10, 28, 30, 50, 50x1, 60, 98, 100, 100x1 and 500 prolonged-release tablets Aluminium/PVC/PVDC blister
Metoprolol tartrate-ratiopharm 50 mg prolonged release tablets Metoprolol tartrate-ratiopharm 100 mg prolonged release tablets
Pack sizes with 10, 28, 30, 50, 50x1, 60, 98, 100, 100x1 and 500 prolonged-release tablets
Tablet container (HDPE) with twist-off cap (PP)
Pack sizes with 100 and 250 prolonged-release tablets
Metoprolol-ratiopharm Retard Retard is containing 10, 14, 28, 30, 50, 56, 60, 84, 90, 98 and 100 tablets in blisters.
Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder:
ratiopharm GmbH,
Graf-Arco-Str. 3,
89079 Ulm Germany
Manufacturer:
Merckle GmbH Ludwig-Merckle-Str. 3,
89143 Blaubeuren Germany
For any information about this medicine, please contact the local representative of the
Marketing Authorisation Holder.
Teva Estonian branch
UAB Sicor Biotech Estonian branch
Hallivanamehe 4
11317 Tallinn,
Phone: +372 6610 801

This patient information leaflet was last revised in December 2017.






  Instruction, annotation source for medicine: State Agency of Medicines, Estonia




[*1]

DDD. Information source: WHO Collaborating Centre for Drug Statistics Methodology. Norwegian Institute of Public Health


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