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HJERTEMAGNYL (ASPIR+MgO) 75MG TBL N100

Attention: Information on this site is provided for informational purposes and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for treating a health problem or disease, or prescribing any medication. iDrugs24.com is not responsible for any damage to your health as the result of self treatment.

# On 2024-Mar-29
HJERTEMAGNYL-ASPIR-drug/medicine -tablets aproximate price on "HJERTEMAGNYL (ASPIR+MgO) 75MG TBL N100" in Riga city, Latvia is:
  • 3.96€  4.28$  3.39£  457Rub  45.6SEK  17PLN  15.76₪ 

HJERTEMAGNYL, 75 mg, plėvele dengtos tabletės, N100


Maximum allowed state defined price ( from ZVA webpage) Euro:State defined maximum allowed price indicated on the picture on drug/medicine -tablets  HJERTEMAGNYL (ASPIR+MgO) 75MG TBL N100     Recheck

ATC codeB01AC06 

Active substances: Acidum Acetylsalicylicum

 


Vendor, principal: Nycomed Danmark As
No prescription needed/Patient care products, dressings, gloves, medical devices,...

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HJERTEMAGNYL 75 mg/10,5 mg tabletes, 100 gab.

 .

HJERTEMAGNYL 75MG/+10.5MG N100

Package leaflet: information for the user Hjertemagnyl, 75 mg / 10.5 mg film-coated tablets

Acetylsalicylic acid / magnesium oxide

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.
-   Keep this leaflet. You may need to read it again.
-   Ask your pharmacist if you need more information or advice.
-   You must talk to a doctor if you do not feel better or if you feel worse.
-   If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet

1.   What Hj ertemagnyl is and what it is used for
2.   What you need to know before you use Hjertemagnyl
3.   How to use Hj ertemagnyl
4.   Possible side effects
5.   How to store Hjertemagnyl
6.   Contents of the pack and other information

1. What Hjertemagnyl is and what it is used for

Hjertemagnyl is an antithrombotic medicine, which is used in the following cases:
Prophylaxis of coronary thrombosis (coronary artery blockage):
-   in the case of suspected myocardial infarction and post-myocardial infarction;
-   in the case of angina (chest pain);
-   after a coronary revascularisation (restoration of blood vessels and blood flow) procedure;
-   reducing the risk of primary myocardial infarction in the case of concomitant cardiovascular risk factors.
Prophylaxis of cerebral thrombosis:
-   after a transient cerebral ischemic attack (lack of blood flow to the brain);
-   after an ischemic stroke (due to topical lack of blood flow).
If your doctor has prescribed this medicine for another indication, follow the doctor’s instructions.
You must talk to a doctor if you do not feel better or if you feel worse.

2. What you need to know before you use Hjertemagnyl

Do not take Hjertemagnyl:

-   if you are allergic to the active substances or any of the other ingredients of this medicine (listed in section 6);
-   if you have had an allergic reaction, such as asthma, runny nose, or itchy rash after taking medicine that contains acetylsalicylic acid (e.g. aspirin) or to other medicines relieving pain and inflammation (NSAIDs);
-   if you have recently had a gastrointestinal haemorrhage;
-   if you    have a stomach or duodenal ulcer disease;
-   if you    have recently had a cerebral haemorrhage;
-   if you have a lack of platelets in the blood (thrombocytopenia) or a tendency to bruise (Vitamin K deficiency, haemophilia);
-   if you    have severe liver failure, hepatic cirrhosis;
-   if you    have severe renal failure;
-   if you    have severe heart failure;
-   if you    have been prescribed treatment with 15 mg or more    of methotrexate per week;
-   if you    are in the last trimester of pregnancy (dose exceeds    100    mg per day).
If you have any of the listed contraindications, talk to your doctor or pharmacist before taking this medicine.

Warnings and precautions

Caution is advised in the case of the following conditions/diseases:
-   if you have asthma or allergy (taking acetylsalicylic acid may trigger an asthma attack and a bronchospasm);
-   if you have liver or kidney function damage;
-   if you have uncontrolled hypertension;
-   if you are concomitantly using anticoagulants.
The long-term concomitant use of Hjertemagnyl with non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided due to an increased risk of side effects.
Doses higher than 100 mg per day should not be used in the last trimester of pregnancy.
Caution is advised if you are prone to dyspepsia or if you have a gastric mucosal injury or ulcer. The elderly should avoid prolonged use of Hjertemagnyl due to an increased risk of gastrointestinal haemorrhage.

Children

In young children, the use of magnesium hydroxide may cause hyperglycaemia, especially in case of renal impairment or dehydration.
Without consulting a doctor, acetylsalicylic acid is not recommended for children and adolescents younger than 16 years in the case of viral infections with or without a fever (incl. chickenpox, the influenza), as Reye’s syndrome may occur (a life-threatening condition characterised by encephalopathy (impairment of the central nervous system), abnormal hepatic function; prolonged vomiting as the first symptom).
Reye’s syndrome is a very rare but possibly life-threatening condition that requires immediate medical attention.
Talk to your doctor or pharmacist before using Hjertemagnyl.

Other medicines and Hjertemagnyl

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
Hjertemagnyl may reduce the effect of the following medicines:
-   diuretics containing spironolactone and furosemide;
-   medicines that promote the excretion of uric acid (probenecid);
-   ACE inhibitors (medicines that lower blood pressure). Concomitant use increases the risk of acute renal failure (especially in patients with pre-existing renal impairment);
-   antacids and H2 blockers.
Hjertemagnyl may increase the effect of the following medicines:
-   medicines inhibiting blood clotting (e.g. coumarin derivatives, heparin);
-   diabetes medicines;
-   methotrexate, which is used in chemotherapy and in some forms of gout.
The concomitant use of acetylsalicylic acid with other non-steroidal anti-inflammatory medicines, COX-2 inhibitors (e.g. celecoxib), or glucocorticoids may increase the risk of gastrointestinal haemorrhage.
The concomitant use of Hjertemagnyl with the following medicines increases the risk of haemorrhage:
-   platelet aggregation inhibitors (warfarin, dicoumarol, ticlopidine);
-   quinidine;
-   selective serotonin reuptake inhibitors    (SSRIs);
-   ginkgo biloba preparations.
Concomitant use with acetazolamide (diuretic, used in the treatment of various diseases) causes the toxicity of both salicylates (vomiting, tachycardia, fastened and deep breathing, confusion) and acetazolamide (fatigue, lethargy, sleepiness, confusion, metabolic acidosis with hypokalaemia).
The concomitant use of valproic acid and acetylsalicylic acid changes protein binding and metabolism of valproic acid, which may cause valproic acid poisoning (suppression of the central nervous system, gastrointestinal disorders).
Concomitant use with varicella vaccine increases the risk of developing Reye’s syndrome.
Magnesium hydroxide may affect the effects of certain other medicines, or other medicines may affect the effects of magnesium hydroxide. Inform your doctor or pharmacist if you take salicylates.
Check with your doctor or pharmacist if you are not sure about the concomitant use of these medicines.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Pregnancy
During pregnancy, use the lowest effective dose of acetylsalicylic acid.
In the last trimester of pregnancy, acetylsalicylic acid is contraindicated in doses exceeding 100 mg/day.
The use of NSAIDs may increase the risk of miscarriage, cardiac malformations, and gastroschisis.
In several epidemiological studies, the use of salicylates in the first trimester of pregnancy has been associated with the heightened risk of malformations (cleft palate, cardiac malformations). The risk is small when taking normal therapeutic doses: in a prospective study with approximately 32,000 mother-child pairs, the link with an increase in the incidence of malformations did not occur.
Salicylates may be used during pregnancy only after careful evaluation of the risk-benefit balance.
The use of large doses of salicylates (> 300 mg/day) in the last trimester of pregnancy may cause prolongation of gestation time, premature closure of ductus arteriosus and inhibition of uterine contractions. An increased predisposition to bleeding has been observed in both mother and child.
Administration of large doses (> 300 mg/day) of acetylsalicylic acid shortly before giving birth may cause the formation of intracranial bruises, especially in premature infants.
Breast-feeding
Salicylates and their metabolites are excreted in breast milk in small quantities. Existing data are not sufficient to assess the risks to infants during breast-feeding. Before using salicylates while breast-feeding, the benefits of the medicine and potential risks to the infant should be assessed. Breast-feeding should be discontinued in the case of prolonged use and/or administration of larger doses.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines

Hjertemagnyl does not have or has negligible effect on the ability to drive and use machines.

3. How to use Hjertemagnyl

Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.
Check with your doctor or pharmacist if you are not sure.
The recommended initial dose in acute conditions (e.g. myocardial infarction or unstable angina) in adults is 24 tablets (150-300 mg) per day as a single dose. In the case of prolonged treatment, the recommended maintenance dose is 1-2 tablets (75-150 mg) per day. For later prophylaxis, the sufficient dose is 1 tablet (75 mg).
Use in patients with hepatic and renal impairment
Contraindicated or use with caution.

Use in children

In children and adolescents younger than 15 years, the medicine may only be used if prescribed by a doctor (see section “Warnings and precautions”).
If you feel that the effect of Hjertemagnyl is too strong or too weak, consult your doctor or pharmacist.
Take the tablet with a glass of water. The tablets may be swallowed whole, halved if necessary, chewed or crushed.

If you take more Hjertemagnyl than you should

Mild poisoning occurs in the case of repeated administration of large doses. The symptoms include fever, tachypnea, respiratory alkalosis, metabolic acidosis, lethargy, mild dehydration, nausea, vomiting and murmur in the ears.
The symptoms of a severe overdose or acute poisoning include hypoglycaemia (especially in children), encephalopathy, coma, hypotension, pulmonary oedema, cramps, coagulopathy, cerebral oedema and cardiac arrhythmia.
Usually, poisoning symptoms are more severe in patients with prolonged overdosing, in the elderly with other health problems, and in infants.
In children, acute poisoning may occur from a single dose of 150 mg/kg acetylsalicylic acid or if the dose of 100 mg/kg per day is administered for more than 2 days.
In adults, poisoning may occur from doses of more than 300 mg/kg.
There is no specific antidote. Lavage with activated charcoal and hospitalisation where appropriate should be implemented to treat poisoning.
In the event of overdose symptoms, contact your doctor. Show your doctor the pack of this medicine.
If you have any further questions on the use of this medicine, consult your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Common side effects (may affect more than 1 user in 100):
prolongation of clotting time, inhibition of platelet clumping, headache, insomnia, obstruction of small airways in asthma patients; redness and superficial ulceration of the oesophageal, stomach and duodenal mucosa; nausea, vomiting, diarrhoea.
Uncommon side effects (may affect more than 1 user in 1,000):
hidden bleeding due to clinically concealed haemorrhage, severe allergic reactions, dizziness, drowsiness, tinnitus (secondary sound heard in the ears or head), ulceration and haemorrhage of the oesophagus, stomach or the duodenum, including haematemesis and melena, hives and intermittent localised oedema formation.
Rare side effects (may affect less than 1 user in 1,000):
anaemia in the case of prolonged treatment, low blood sugar levels, intracerebral haemorrhage, dose-dependent reversible hearing loss and deafness; severe haemorrhage and rupture of the oesophagus, stomach or the duodenum; increased levels of transaminases.
Very rare side effects (may affect less than 1 user in 10,000):
too low levels of prothrombin (blood component required for blood clotting) in the case of large doses; lack of platelets, changes in white blood cell count; gingivitis, inflammation of the oesophagus, large bowel disorders (ulceration, narrowing, inflammation of the large intestine or exacerbation of the inflammatory bowel disease), dose-dependent mild, reversible toxic liver damage at the time of some viral infections, purpura (red skin rash), haemorrhagic vasculitis (blood vessel inflammation), erythema multiforme (redness of the skin), StevensJohnson syndrome and Lyell’s syndrome, hypermagnesaemia (seen in long-term administration in patients with renal impairment).
Unknown (incidence cannot be estimated from available data):
abdominal pain.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via www.ravimiamet.ee. By reporting side effects, you can help provide more information on the safety of this medicine.

5. How to store Hjertemagnyl

Keep this medicine out of the sight and reach of children.
Do not store at a temperature higher than 25 °C.
Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines that you no longer use. These measures will help protect the environment.

6. Contents of the pack and other information What Hjertemagnyl contains

-   The active substances are acetylsalicylic acid and magnesium oxide. One film-coated tablet contains 75 mg of acetylsalicylic acid and 10.5 mg of magnesium oxide (as magnesium hydroxide).
-   The other ingredients are potato starch, magnesium stearate, maize starch, microcrystalline cellulose, hypromellose, propylene glycol and talc.

What Hjertemagnyl looks like and contents of the pack

Hjertemagnyl is a white heart-shaped tablet.
Packaged in a glass bottle and carton. The pack contains 100 tablets.

Marketing Authorisation Holder and Manufacturer

Takeda Pharma AS Jaama 55B 63308 Pölva Estonia
Telephone +372 7998100

The leaflet was last revised in August 2018.






  Instruction, annotation source for medicine: State Agency of Medicines, Estonia





• Medicaments images are for illustrative purposes only and may differ from the actual product.


[*1]

DDD. Information source: WHO Collaborating Centre for Drug Statistics Methodology. Norwegian Institute of Public Health


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