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IBUPROFEN GRINDEKS TBL 200MG N20

Attention: Information on this site is provided for informational purposes and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for treating a health problem or disease, or prescribing any medication. iDrugs24.com is not responsible for any damage to your health as the result of self treatment.

# On 2024-Mar-29
IBUPROFEN-drug/medicine -tablets aproximate price on "IBUPROFEN GRINDEKS TBL 200MG N20" in Riga city, Latvia is:
  • 1.68€  1.82$  1.44£  194Rub  19.4SEK  7PLN  6.69₪ 

IBUPROM, 200 mg, dengtos tabletės, N20


Maximum allowed state defined price ( from ZVA webpage) Euro:State defined maximum allowed price indicated on the picture on drug/medicine -tablets  IBUPROFEN GRINDEKS TBL 200MG N20     Recheck

ATC codeM01AE01 

Active substances: Ibuprofenum

 

Latvijas zāles medikaments Made in Latvia. 
Vendor, principal: Grindeks A/s
No prescription needed/Patient care products, dressings, gloves, medical devices,...

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IBUPROFEN GRINDEKS 200 mg tabletes, 20 gab.

 .

IBUPROFEN-GRINDEKS 200MG N20

Package leaflet: Information for the user

Ibuprofen-Grindex, 200 mg film-coated tablets

Ibuprofen

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.
-   Keep this leaflet. You may need to read it again.
-   Ask your pharmacist if you need more information or advice.
-   If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.
-   You must talk to a doctor if you do not feel better or if you feel worse.

What is in this leaflet

1.   What Ibuprofen-Grindeks is and what it is used for
2.   What you need to know before you use Ibuprofen-Grindeks
3.   How to use Ibuprofen-Grindeks
4.   Possible side effects
5.   How to store Ibuprofen-Grindeks
6.   Contents of the pack and other information

1. What Ibuprofen-Grindeks is and what it is used for

Ibuprofen-Grindeks contains the active substance ibuprofen. It is an analgesic (painkiller) with anti-inflammatory and fever-reducing effects.
Ibuprofen-Grindeks is used for reduction of fever and short-term treatment of weak to moderate pain, such as menstrual pain, headache, toothache, and muscular and joint pain.

2. What you need to know before you use Ibuprofen-Grindeks

Do not use Ibuprofen-Grindeks:

-   if you are allergic to ibuprofen or any of the other ingredients of this medicine;
-   if you are hypersensitive to salicylates or any other nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g. indomethacin, diclofenac sodium) - you may develop an asthma attack, a rash or allergic rhinitis;
-   if you have unexplained haematopoietic (production of blood cells) disorders;
-   if you have severe liver impairment (cirrhosis of the liver), severe heart failure and/or severe kidney disease;
-   concurrently with other NSAIDs (including medicines called cyclooxygenase-2 specific inhibitors);
-   if NSAID use has previously caused you gastrointestinal bleeding or perforation;
-   if you have a history of acute or relapsing gastrointestinal ulcer/bleeding (two or more definite cases of ulcer or bleeding);
-   if you have significant dehydration - due to vomiting, diarrhoea or insufficient liquid use;
-   during the third trimester of pregnancy;
-   in children under 12 years of age.
Tell your doctor before taking the medicine if any of the above applies to you.

Warnings and precautions

Side effects may be reduced by using the minimal effective dose during as short a time as possible to control the symptoms.
Talk to your doctor or pharmacist before taking Ibuprofen-Grindeks:
-   if you suffer from a disease called systemic lupus erythematosus or SLE (a disease affecting connective tissue, including joints and skin);
-   if you are an elderly patient (due to increased risk of severe side effects);
-   if you have problems with your heart, if you have recently had a stroke    or if you
think that you are at risk for developing such conditions (for example if you have high blood pressure, diabetes or high blood cholesterol, or if you smoke);
-   if you have suffered from intestinal diseases such as ulcerative colitis or Crohn's disease (these conditions may worsen);
-   if you suffer or have suffered from asthma or an allergic disease;
-   if you have asthma-related chronic rhinitis, chronic sinus infection and/or    nasal
polyps (increased risk of allergic reactions);
-   if you have liver or kidney problems.
Anti-inflammatory/analgesic medications like ibuprofen may be associated with mildly increased risk of heart attack and stroke. The risk is more probable when large doses are used. Do not exceed the recommended doses and duration of the treatment.
Talk to your doctor or pharmacist before taking Ibuprofen-Grindeks in the following cases:
-   if you have cardiac problems, such as cardiac insufficiency, stenocardia (chest pain) or if you have had a heart attack, bypass surgery, peripheral artery disease (poor blood flow into the legs or feet due to narrowed or clogged arteries) or any kind of stroke (including ministroke or transitory ischemic attack (TIA))
-   if you have high blood pressure, diabetes or high cholesterol, if you have a family history of cardiac disease or stroke or if you smoke
Avoid using other NSAIDs, including selective cyclooxygenase-2 inhibitors, while you use Ibuprofen-Grindeks.
You are at a higher risk of gastrointestinal bleeding, ulceration and/or perforation, if your NSAID dosage has been increased or if you have previously had a gastrointestinal ulcer, especially in the case of a complicated ulcer with bleeding and perforation, and also if you are an elderly patient. If possible, your treatment should be initiated with the lowest dose.
Inform your doctor if you get any unusual gastrointestinal symptoms (especially gastrointestinal bleeding), especially if these occur during the beginning of treatment.
If gastrointestinal bleeding or an ulcer occurs during therapy with ibuprofen, treatment should be discontinued immediately.
Patients treated with ibuprofen should report blurred vision or other eye symptoms, skin rash, increases in body weight or swelling.
Be careful while using the medicine if you have a bleeding disorder, also in the case of the concurrent administration of coumarin derivatives (medicines preventing blood clotting).
In patients with asthma, respiratory disease with pulmonary obstruction, hay fever, chronic swelling of nasal mucous membrane (nasal polyps), or chronic respiratory infection (with concomitant hay fever-like symptoms), ibuprofen may cause an asthma attack (so-called analgesic intolerance/analgesic asthma), soft tissue (tongue, face, neck and throat) swelling, or urticaria (nettle rash).
Patients suffering from induced porphyria and systemic connective tissue disease (lupus erythematosus and mixed collagenosis) should take special care.
Patients with a history of gastrointestinal diseases (ulcerative colitis and Crohn's disease) should use NSAIDs with caution and under medical supervision.
Precaution should be taken by patients who concurrently use medications that increase the risk of gastrointestinal ulcers and bleeding (such as oral corticosteroids), medicines preventing blood clotting (anticoagulants, e.g. warfarin), selective serotonin reuptake inhibitors (certain antidepressants), or inhibitors of thrombocyte aggregation (such as acetylsalicylic acid).
Serious skin reactions, some of which may be lethal (including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis), have occurred rarely during the use of NSAIDs. The risk of skin reaction is highest in the early treatment period (especially in the first month of treatment).
Discontinue Ibuprofen-Grindeks use immediately if skin rash, mucous membrane damage or any other hypersensitivity symptoms occur.
Caution should be exercised in dehydrated patients, especially adolescents and the elderly. Dehydrated adolescents have a risk of developing renal damage.
Habitual use of analgesics (especially if a combination of several analgesic agents is taken) can lead to permanent renal damage with the risk of developing renal insufficiency (analgesic nephropathy).

Children

This medication is not suitable for children under 12 years of age due to high active ingredient content.

Other medicines and Ibuprofen-Grindeks

Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.
Avoid using anticoagulants (medicines preventing blood clotting)(e.g. acetylsalicylic acid, warfarin, ticlopidine), some of the antihypertensive agents (ACE-inhibitors, e.g. captopril, beta-blockers, angiotensin II inhibitors) and some other medicines, because these may influence the effect of ibuprofen, or ibuprofen may influence the effect of these medicines.
Ibuprofen-Grindeks may influence the effect of some medicines, or other medicines may influence the effect of Ibuprofen-Grindeks. For example:
•   medications called anticoagulants (e.g. blood thinners / anti-clotting agents, such as aspirin or acetylsalicylic acid, warfarin, ticlopidine)
•   medications that lower blood pressure (ACE inhibitors, such as captopril, beta blockers, such as atenolol, angiotensin II receptor antagonists, such as losartan);
•   methotrexate (medicine for the treatment of tumours);
•   antihypertensive agents and diuretics (e.g. hydrochlorothiazide, furosemide);
•   cardiac glycosides such as digoxin (for the treatment of heart failure);
•   corticosteroids;
•   pentoxifylline (for treatment of peripheral circulation disorders);
•   lithium preparations (for treatment of bipolar disorder or depression);
•   selective serotonin re-uptake inhibitors (antidepressants, e.g. moclobemide);
•   cyclosporine (an immunosuppressive drug);
•   probenecid (for the treatment of gout);
•   tacrolimus (immunosuppressive drug);
•   mifepristone (for the termination of pregnancy); NSAIDs may reduce the effect of mifepristone;
•   quinolone antibiotics (e.g. ciprofloxacin);
•   aminoglycoside antibiotics (e.g. gentamycin);
•   zidovudine (for the treatment of AIDS); thrombocyte aggregation inhibitors.
Some other medications may also influence the effect of Ibuprofen-Grindeks, or Ibuprofen-Grindeks may influence their effect. Therefore, you should always talk to your doctor or pharmacist before using Ibuprofen-Grindeks in combination with any other medications.

Ibuprofen-Grindeks with food, drink and alcohol

In the case of gastrointestinal disorders take this medicine with food or milk.
Avoid alcohol consumption during treatment with this medicine, since alcohol may amplify the possible side effects.

Pregnancy, breast-feeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Pregnancy
Although there are no reports of teratogenicity in literature, Ibuprofen-Grindeks like all other nonsteroidal anti-inflammatory drugs is not recommended until the 20th week of pregnancy as the inhibitors of prostaglandin synthesis have an unfavourable effect on pregnancy and/or the foetus/newborn (higher risk of miscarriage and heart malformations have been observed in epidemiological studies).
Prostaglandin inhibitors are contraindicated for use from the third trimester of pregnancy. Due to the effect of prostaglandin inhibitors the ductus arteriosus may close prematurely, postnatal bleeding time may be prolonged and uterine contractions may be reduced, which leads to longer labour.
Breast-feeding
The active ingredient ibuprofen is excreted in breast milk only in very minimal amounts and thus is probably not harmful for the child. It is not necessary to stop breast-feeding if therapeutic doses are used over a short period of time.
Breast-feeding should be discontinued if longer-term treatment is needed.
Ask your doctor or pharmacist for advice before taking the medicine.
Fertility
Some evidence exists that anti-inflammatory and analgesic medicines (including ibuprofen) may impair fertility in women. This disorder is reversible when use of the medicine is discontinued.
It is unlikely that Ibuprofen-Grindeks, used occasionally, will affect your chances of becoming pregnant. However, tell your doctor before taking this medicine if you have problems becoming pregnant.

Driving and using machines

Patients with dizziness, other central nervous system disorders or impaired vision should avoid driving and using machines.

Ibuprofen-Grindeks contains the colouring agent azorubine (E 122)

The colouring agent azorubine (E 122) may cause allergic reactions.

3. How to use Ibuprofen-Grindeks

Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
The medicine is meant only for short-term use. For symptom relief, the lowest effective dose during the shortest possible time should be used.
The tablet should be taken with a sufficient amount of liquid.
In the case of gastrointestinal disorders take this medicine with food or milk.
Adults and adolescents above 12 years of age
The recommended dose is 200-400 mg of ibuprofen (1-2 tablets) 3 times per day. Do not exceed the maximum permitted dose of 1200 mg of ibuprofen (6 tablets) per every 24 hours. There should be an at least a 4-hour interval between administrations.
Consult your doctor if you use the medicine for more than 3 days for fever or more than 10 days for pain, or if the symptoms worsen. Talk to a doctor if this medicine is required for more than three days in an adolescent patient, or if the symptoms of mild to moderate pain and/or fever worsen.
Elderly
Dosage adjustment is not necessary. Elderly patients should be observed with special care due to the risk of possible side effects (see Warnings and precautions).
Patients with liver and/or kidney impairment
Dosage adjustment is not necessary in the case of mild impairment of kidney and/or liver function. This medicine should not be used in the case of severe kidney and/or liver impairment (see Do not use Ibuprofen-Grindeks).
If symptoms persist, contact your doctor.

Use in children

Ibuprofen-Grindex 200 mg film-coated tablets are contraindicated for use in children under 12 years.

If you use more Ibuprofen-Grindeks than you should

Symptoms of overdose: headache, dizziness, gastrointestinal bleeding, drowsiness, loss of consciousness, abdominal pain, nausea and vomiting, increased blood potassium level, decrease in blood pressure, changes in blood clotting parameters, tissue acidity due to the accumulation of acidic metabolic products, increased body temperature, respiratory failure, convulsions, disorientation, coma, acute kidney impairment.
Contact your doctor immediately if you develop signs of overdose or if you suspect an overdose. Take the medication package with you.

If you forget to use Ibuprofen-Grindeks

Do not take a double dose to make up for a forgotten dose.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets
them.
Side effects may be reduced by using the minimal effective dose during as short a time
as possible to control the symptoms.
Stop using this medicine and turn to a doctor immediately, if you experience any of
the following symptoms:
-   symptoms of stomach and intestinal ulcers or perforation, such as bright red blood in stool, black tar-like stools, vomiting blood;
-   symptoms of kidney problems (renal papillary necrosis), such as the appearance of blood in the urine, and pain on the side of the body;
-   symptoms of severe allergic reactions (anaphylaxis, angioedema), such as swelling of face, tongue or throat, breathing difficulties, increased heart rate, drop in blood pressure leading to shock;
-   potentially life-threatening severe skin rashes with blisters and bleeding on the lips, eyes, mouth and genitals (Steven-Johnson syndrome), or severe skin reactions starting with painful red areas, formation of large blisters and ending with the peeling of the skin layers. This is accompanied by fever and chills, muscle pain and general malaise (toxic epidermal necrolysis);
-   symptoms of aseptic meningitis (infection of the lining of the brain or spinal cord), such as stiff neck, headache, vomiting, fever and disorientation; patients with autoimmune disorders (systemic lupus erythematosus, mixed collagenosis) are at a higher risk.
These side effects are very rare and may affect up to 1 in 10,000 people.
Other side effects you should tell your doctor about:
Common (may affect up to 1 in 10 people)
-   abdominal pain, indigestion, nausea
Uncommon (may affect up to 1 in 100 people)
-   drowsiness, headache
Rare (may affect up to 1 in 1,000 people)
-   skin rash, itching, angioedema (including epidermal necrolysis, exfoliative dermatitis, erythema multiforme)
-   diarrhoea, bloated stomach, constipation, vomiting
Very rare (may affect up to 1 in 10,000 people)
-   hematopoietic system disorders (anaemia, hemolytic anaemia, aplastic anaemia, leucopenia, thrombocytopenia, pancytopenia, agranulocytosis); primary symptoms may be: fever, sore throat, swelling of the mouth, flu-like symptoms, severe tiredness, nose bleed
-   drowsiness, nervousness, depression, insomnia
-   vision disorders
-   tinnitus (noises or ringing in the    ears)
-   asthma, bronchospasm, shortness of breath and breathing difficulties
-   peptic ulcer, perforation or gastrointestinal bleeding, exacerbation of ulcerative colitis or Crohn's disease, ulcerative stomatitis, gastritis
-   liver impairment with jaundice, hepatitis or increasing activity of liver enzymes (especially with long-term use), pancreatitis
-   kidney inflammation, papillary necrosis, kidney damage
-   decreased urine secretion and swelling
-   increased serum    uric    acid    levels
-   photosensitivity    reaction,    fever
-   lower limb swelling
-   decreased haematocrit and blood haemoglobin levels
Not known (frequency cannot be estimated from the available data)
-   increase in blood pressure
-   heart failure
-   runny nose
Medications like Ibuprofen-Grindeks may be associated with mildly increased risk of heart attack and stroke (see Warnings and precautions).
Ibuprofen may impair fertility in women. This disorder is reversible when use of the medicine is discontinued (see Pregnancy, breast-feeding and fertility).

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via www.ravimiamet.ee. By reporting side effects you can help provide more information on the safety of this medicine.

5. How to store Ibuprofen-Grindeks

Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton.
The expiry date refers to the last day of that month. Store in original package, protected from light.
Do not store above 25°C. Store in original package, protected from light.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.

6. Contents of the pack and other information

What Ibuprofen-Grindeks contains

-   The active substance is ibuprofen (Ibuprofenum).
Each film-coated tablet contains 200 mg of ibuprofen.
-   The other ingredients are:
Tablet core: microcrystalline cellulose, corn starch, croscarmellose sodium, stearic acid, silica colloidal anhydrous (Aerosil 200).
Tablet coating: colouring agent Opadry Pink 85F 24678 (polyvinyl alcohol, titanium dioxide (E171); macrogol 3000; talc, azorubine (E 122), iron oxide black (E172), iron oxide yellow (E172), carnauba wax.

What Ibuprofen-Grindeks looks like and contents of the pack

Light pink or pinkish-white, round, film-coated, biconvex tablets.
10 film-coated tablets in a PVH/Al blister package.
2 or 5 blister packages (20-50 tablets) in a cardboard box.
Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

AS GRINDEKS
Krustpils iela 53, Rīga, LV-1057, Latvia Tel.: +371 67083205 Fax: +371 67083505 e-mail: [email protected]
For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder:
AS Grindeks Estonian branch Tondi 33, 11316, Tallinn, Estonia Tel: +372 6120224 Fax: +372 6120331
This leaflet was last revised in May 2017.





  Instruction, annotation source for medicine: State Agency of Medicines, Estonia





• Medicaments images are for illustrative purposes only and may differ from the actual product.


[*1]

DDD. Information source: WHO Collaborating Centre for Drug Statistics Methodology. Norwegian Institute of Public Health


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